HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 59228

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
Variants
RPQVPLRaMTY   HLA association
Epitope Name RY11
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3367
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  RPQVPLRaMTY
Mutations P/A
Epitope Location P8A
HXB2 Location P78A
Mutation Type A: HLA association
Epitope Subtype B
Variant Subtype B
Method HLA binding, Other, Structural prediction
Note Complex of B*3501 with variant P8A of RY11, RPQVPLRaMTY, is more stable than B*3501-RY11, but specificity to the cognate TCR is maintained.

References

Yanaka2014 Saeko Yanaka, Takamasa Ueno, Yi Shi, Jianxun Qi, George F. Gao, Kouhei Tsumoto, and Kenji Sugase. Peptide-Dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex. J. Biol. Chem., 289(35):24680-24690, 29 Aug 2014. PubMed ID: 25028510. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health