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Found 1 matching record:

Displaying record number 59209

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   observed variant
QASQtVKNW   observed variant
Epitope Name QW9
Species (MHC/HLA human(B*5701)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3356
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E312D
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant QASQdVKNW was seen in 2/3 HRP and no LRP subjects. It was the analogous epitope of the major viral population at the last time points in patient P3, the earliest time point in patient P1.


Variant ID.  3357
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQtVKNW
Mutations E/T
Epitope Location E5T
HXB2 Location E312T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant QASQtVKNW was seen in 1/3 HRP and no LRP subjects. It was the only analogous epitope of the major viral population patient P2.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


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