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Displaying record number 59203

HXB2 Location  Nef(126-135)   Nef Epitope Map
View variants at this location
Epitope NYTPGPGIRY   Epitope Alignment
Variants
NYTPGPGvRY   observed variant
cYTPGPGtRY   observed variant
NYTPGPGtRY   observed variant
NYTPGPGIRf   observed variant
NYTPGPGtRf   observed variant
cYTPGPGIRf   observed variant
gYTPGPGIRf   observed variant
cYTPGPGtRf   observed variant
gYTPGPGtRf   observed variant
NYTPGPGvRf   observed variant
NYTPGPGeRf   observed variant
NYTPGPGvRl   observed variant
NYTPGPGtRw   observed variant
Epitope Name Nef126-10
Species (MHC/HLA human(A*2402)

Variant Details

Showing all: 13 variant(s).


Variant ID.  3326
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGvRY
Mutations I/V
Epitope Location I8V
HXB2 Location I133V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, NYTPGPGvRY, in epitope Nef126-10: Nef126-143 sequence, NYTPGPGvRYPLTFGWCF exists in that subject.


Variant ID.  3327
Epitope Seq.  NYTPGPGIRY
Variant Seq.  cYTPGPGtRY
Mutations N/C I/T
Epitope Location N1C I8T
HXB2 Location N126C I133T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, cYTPGPGtRY, in epitope Nef126-10: Nef126-143 sequence, cYTPGPGtRYPLTFGWCF exists in that subject.


Variant ID.  3328
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGtRY
Mutations I/T
Epitope Location I8T
HXB2 Location I133T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 2/46 subjects carried this sequence, NYTPGPGtRY, in epitope Nef126-10: Nef126-143 sequence, NYTPGPGtRYPLTFGWCF exists in 1 subject and NYTPGPGtRYPLcFGWCF in the other.


Variant ID.  3329
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGIRf
Mutations Y/F
Epitope Location Y10F
HXB2 Location Y135F
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 2/46 subjects carried this 8I10F variant sequence, NYTPGPGIRf, in epitope Nef126-10: Nef126-143 sequence, NYTPGPGIRfPLTFGWCF exists in those subjects. NYTPGPGIRf(8I10F)-specific CTL responses were inversely correlated with plasma viral load (pVL).


Variant ID.  3330
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGtRf
Mutations Y/F I/T
Epitope Location Y10F I8T
HXB2 Location Y135F I133T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 23/46 (50%) subjects carried this sequence, NYTPGPGtRf (8T10F), in epitope Nef126-10: Nef126-143 sequence, NYTPGPGtRfPLTFGWCF exists in those subjects. NYTPGPGtRf(8T10F)-specific CTL responses were not inversely correlated with pVL. The I133T mutation shortly followed the Y135F one.


Variant ID.  3331
Epitope Seq.  NYTPGPGIRY
Variant Seq.  cYTPGPGIRf
Mutations N/C Y/F
Epitope Location N1C Y10F
HXB2 Location N126C Y135F
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, cYTPGPGIRf, in epitope Nef126-10: Nef126-143 sequence, cYTPGPGIRfPLTFGWCF exists in that subject.


Variant ID.  3332
Epitope Seq.  NYTPGPGIRY
Variant Seq.  gYTPGPGIRf
Mutations N/G Y/F
Epitope Location N1G Y10F
HXB2 Location N126G Y135F
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, gYTPGPGIRf, in epitope Nef126-10: Nef126-143 sequence, gYTPGPGIRfPLTFGWCF exists in that subject.


Variant ID.  3333
Epitope Seq.  NYTPGPGIRY
Variant Seq.  cYTPGPGtRf
Mutations N/C Y/F I/T
Epitope Location N1C Y10F I8T
HXB2 Location N126C Y135F I133T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, cYTPGPGtRf, in epitope Nef126-10: Nef126-143 sequence, cYTPGPGtRfPLTFGWCF exists in that subject.


Variant ID.  3334
Epitope Seq.  NYTPGPGIRY
Variant Seq.  gYTPGPGtRf
Mutations N/G Y/F I/T
Epitope Location N1G Y10F I8T
HXB2 Location N126G Y135F I133T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, gYTPGPGtRf, in epitope Nef126-10: Nef126-143 sequence, gYTPGPGtRfPLTFGWCF exists in that subject.


Variant ID.  3335
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGvRf
Mutations Y/F I/V
Epitope Location Y10F I8V
HXB2 Location Y135F I133V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 4/46 subjects carried this sequence, NYTPGPGvRf, in epitope Nef126-10: Nef126-143 sequence, NYTPGPGvRfPLTFGWCF exists in those subjects.


Variant ID.  3336
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGeRf
Mutations Y/F I/E
Epitope Location Y10F I8E
HXB2 Location Y135F I133E
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, NYTPGPGeRf, in epitope Nef126-10: Nef126-143 sequence, NYTPGPGeRfPLcFGWCF exists in that subject.


Variant ID.  3337
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGvRl
Mutations Y/L I/V
Epitope Location Y10L I8V
HXB2 Location Y135L I133V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 2/46 subjects carried this sequence, NYTPGPGvRl, in epitope Nef126-10: Nef126-143 sequence, NYTPGPGvRlPLTFGWCF exists in those subjects.


Variant ID.  3338
Epitope Seq.  NYTPGPGIRY
Variant Seq.  NYTPGPGtRw
Mutations Y/W I/T
Epitope Location Y10W I8T
HXB2 Location Y135W I133T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/46 subjects carried this sequence, NYTPGPGtRw, in epitope Nef126-10: Nef126-143 sequence, NYTPGPGtRwPLTFGWCF exists in that subject.

References

Han2014 Chungyong Han, Ai Kawana-Tachikawa, Akihisa Shimizu, Dayong Zhu, Hitomi Nakamura, Eisuke Adachi, Tadashi Kikuchi, Michiko Koga, Tomohiko Koibuchi, George F. Gao, Yusuke Sato, Atsushi Yamagata, Eric Martin, Shuya Fukai, Zabrina L. Brumme, and Aikichi Iwamoto. Switching and Emergence of CTL Epitopes in HIV-1 Infection. Retrovirology, 11:38, 2014. PubMed ID: 24886641. Show all entries for this paper.


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