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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 59184

HXB2 Location  Nef(188-196)   Nef Epitope Map
View variants at this location
Epitope TLAFHHVAR   Epitope Alignment
Variants
TLAFHHaAR   diminished response
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3310
Epitope Seq.  TLAFHHVAR
Variant Seq.  TLAFHHaAR
Mutations V/A
Epitope Location V7A
HXB2 Location V194A
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Sequence
Note Acute controller, AC01, carried the Nef TLAFHHVAR mutant, TLAFHHaAR at V194A, and had a diminished effect, decreasing downregulation of MHC Class I molecules and increasing CD4 levels.

References

Kuang2014 Xiaomei T. Kuang, Xiaoguang Li, Gursev Anmole, Philip Mwimanzi, Aniqa Shahid, Anh Q. Le, Louise Chong, Hua Qian, Toshiyuki Miura, Tristan Markle, Bemuluyigza Baraki, Elizabeth Connick, Eric S. Daar, Heiko Jessen, Anthony D. Kelleher, Susan Little, Martin Markowitz, Florencia Pereyra, Eric S. Rosenberg, Bruce D. Walker, Takamasa Ueno, Zabrina L. Brumme, and Mark A. Brockman. Impaired Nef Function Is Associated with Early Control of HIV-1 Viremia. J. Virol., 88(17):10200-10213, 1 Sep 2014. PubMed ID: 24965469. Show all entries for this paper.


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