Found 1 matching record:
HXB2 Location | Nef(188-196) | Nef Epitope Map
View variants at this location |
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Epitope |
TLAFHHVAR
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human |
Showing all: 1 variant(s).
Variant ID. | 3310 |
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Epitope Seq. | TLAFHHVAR |
Variant Seq. | TLAFHHaAR |
Mutations | V/A |
Epitope Location | V7A |
HXB2 Location | V194A |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | Longitudinal study, Sequence |
Note | Acute controller, AC01, carried the Nef TLAFHHVAR mutant, TLAFHHaAR at V194A, and had a diminished effect, decreasing downregulation of MHC Class I molecules and increasing CD4 levels. |
Kuang2014 Xiaomei T. Kuang, Xiaoguang Li, Gursev Anmole, Philip Mwimanzi, Aniqa Shahid, Anh Q. Le, Louise Chong, Hua Qian, Toshiyuki Miura, Tristan Markle, Bemuluyigza Baraki, Elizabeth Connick, Eric S. Daar, Heiko Jessen, Anthony D. Kelleher, Susan Little, Martin Markowitz, Florencia Pereyra, Eric S. Rosenberg, Bruce D. Walker, Takamasa Ueno, Zabrina L. Brumme, and Mark A. Brockman. Impaired Nef Function Is Associated with Early Control of HIV-1 Viremia. J. Virol., 88(17):10200-10213, 1 Sep 2014. PubMed ID: 24965469. Show all entries for this paper.
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