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Displaying record number 59181

HXB2 Location Pol(283-290) Pol Epitope Map
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TAFTIPSI

`TAFTIPSv`		escape documented in this paper; replicative capacity reduced; susceptible form
`TAFTvPSv`		escape documented in this paper; susceptible form

Epitope Name TI8

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3308`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSv`
Mutations	I/V
Epitope Location	I8V
HXB2 Location	I290V
Mutation Type	E: escape documented in this paper RCR: replicative capacity reduced SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	Chromium-release assay, CTL suppression of replication, Sequence
Note	Mutant 8V, TAFTIPSv, was seen in all 3 subjects under study. It was selected slowly. It was seen in subjects KI-021 and KI-124 earlier than it was in subject KI-051 who also carried a different mutation in TI8 (TAFTIPSI).

Variant ID.	`3309`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTvPSv`
Mutations	I/V I/V
Epitope Location	I5V I8V
HXB2 Location	I287V I290V
Mutation Type	E: escape documented in this paper SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	Chromium-release assay, CTL suppression of replication, Sequence
Note	Mutant TAFTvPSv, was seen in 1/3 subjects under study. It was selected very slowly in subject KI-051 who also carried a different viral mutation in TI8 (TAFTIPSI).

References

Kuse2014 Nozomi Kuse, Tomohiro Akahoshi, Hiroyuki Gatanaga, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi. Selection of TI8-8V Mutant Associated with Long-Term Control of HIV-1 by Cross-Reactive HLA-B*51:01-Restricted Cytotoxic T Cells. J. Immunol., 193(10):4814-4822, 15 Nov 2014. PubMed ID: 25305317. Show all entries for this paper.