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Displaying record number 59181

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSv   escape documented in this paper; replicative capacity reduced; susceptible form
TAFTvPSv   escape documented in this paper; susceptible form
Epitope Name TI8
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  3308
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay, CTL suppression of replication, Sequence
Note Mutant 8V, TAFTIPSv, was seen in all 3 subjects under study. It was selected slowly. It was seen in subjects KI-021 and KI-124 earlier than it was in subject KI-051 who also carried a different mutation in TI8 (TAFTIPSI).


Variant ID.  3309
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTvPSv
Mutations I/V I/V
Epitope Location I5V I8V
HXB2 Location I287V I290V
Mutation Type E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay, CTL suppression of replication, Sequence
Note Mutant TAFTvPSv, was seen in 1/3 subjects under study. It was selected very slowly in subject KI-051 who also carried a different viral mutation in TI8 (TAFTIPSI).

References

Kuse2014 Nozomi Kuse, Tomohiro Akahoshi, Hiroyuki Gatanaga, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi. Selection of TI8-8V Mutant Associated with Long-Term Control of HIV-1 by Cross-Reactive HLA-B*51:01-Restricted Cytotoxic T Cells. J. Immunol., 193(10):4814-4822, 15 Nov 2014. PubMed ID: 25305317. Show all entries for this paper.


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