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Displaying record number 59123

HXB2 Location Gag(263-272) Gag Epitope Map
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Epitope

KRWIILGLNK

Epitope Alignment

Variants

KRWIImGLNK diminished HLA binding or increased off-rate; escape documented in this paper; observed variant

Epitope Name KK10

Species (MHC/HLA) human(B*27)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3301`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CTL suppression of replication, HLA binding, Sequence
Note	Strain DH12-specific variant of epitope KK10, KRWIImGLNK, was poorly recognized by a strain LAI KK10-specific CTL clone and is an escape variant, that impairs TCR recognition. Suppression of replication of all DH12 viruses was poor.

References

Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.