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Displaying record number 59120

HXB2 Location Nef(73-82) Nef Epitope Map
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Epitope

QVPLRPMTYK

Epitope Alignment

Variants

QiPLRPMTYK diminished HLA binding or increased off-rate; observed variant

Epitope Name QK10

Species (MHC/HLA) human(A*03:01, A*11)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3300`
Epitope Seq.	`QVPLRPMTYK`
Variant Seq.	`QiPLRPMTYK`
Mutations	V/I
Epitope Location	V2I
HXB2 Location	V74I
Mutation Type	DHB: diminished HLA binding or increased off-rate OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CTL suppression of replication, HLA binding, Sequence
Note	Strain DH12-specific variant of epitope QK10, QiPLRPMTYK, was poorly recognized by a strain LAI QK10-specific CTL clone. Suppression of replication of all DH12 viruses was poor.

References

Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.