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Found 1 matching record:

Displaying record number 59120

HXB2 Location  Nef(73-82)   Nef Epitope Map
View variants at this location
Epitope QVPLRPMTYK   Epitope Alignment
Variants
QiPLRPMTYK   diminished HLA binding or increased off-rate; observed variant
Epitope Name QK10
Species (MHC/HLA human(A*0301, A*11)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3300
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QiPLRPMTYK
Mutations V/I
Epitope Location V2I
HXB2 Location V74I
Mutation Type DHB: diminished HLA binding or increased off-rate
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CTL suppression of replication, HLA binding, Sequence
Note Strain DH12-specific variant of epitope QK10, QiPLRPMTYK, was poorly recognized by a strain LAI QK10-specific CTL clone. Suppression of replication of all DH12 viruses was poor.

References

Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.


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