HIV molecular immunology database
Found 1 matching record:
HXB2 Location | Nef(73-82) | Nef Epitope Map
View variants at this location |
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Epitope |
QVPLRPMTYK
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Epitope Alignment | ||||
Variants |
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Epitope Name | QK10 | |||||
Species (MHC/HLA) | human(A*03:01, A*11) |
Showing all: 1 variant(s).
Variant ID. | 3300 |
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Epitope Seq. | QVPLRPMTYK |
Variant Seq. | QiPLRPMTYK |
Mutations | V/I |
Epitope Location | V2I |
HXB2 Location | V74I |
Mutation Type | DHB: diminished HLA binding or increased off-rate OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | CTL suppression of replication, HLA binding, Sequence |
Note | Strain DH12-specific variant of epitope QK10, QiPLRPMTYK, was poorly recognized by a strain LAI QK10-specific CTL clone. Suppression of replication of all DH12 viruses was poor. |
Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.