Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 59114

HXB2 Location Gag(263-272) Gag Epitope Map
View variants at this location

KRWIILGLNK

`KRWIILGLhK`		observed variant; susceptible form
`KRWIImGLNK`		observed variant; susceptible form
`KRWIIiGLNK`		observed variant
`KRWIImGLhK`		observed variant
`KRWIIvGLhK`		observed variant

Epitope Name KK10

Species (MHC/HLA) human(B*27)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4130`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIILGLhK`
Mutations	N/H
Epitope Location	N9H
HXB2 Location	N271H
Mutation Type	OV: observed variant SF: susceptible form
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence, Tetramer binding
Note	CRF01_AE epitope KRWIILGLNK had mutated to the N271H variant KRWIILGLhK in the recipient, N107, at 100% by as early as 20 months post diagnosis, and was seen at 27% and 56% at 42 and 52 mpd.

Variant ID.	`4131`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	OV: observed variant SF: susceptible form
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence, Tetramer binding
Note	CRF01_AE epitope KRWIILGLNK had mutated to the L268M variant KRWIImGLNK in the recipient, N107, to 15% by 52 months post diagnosis but response to it, though reduced from WT KK10-response was detected by EliSpot as early as 20 mpd.

Variant ID.	`4132`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIIiGLNK`
Mutations	L/I
Epitope Location	L6I
HXB2 Location	L268I
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	CRF01_AE epitope KRWIILGLNK had mutated to the L268I variant KRWIIiGLNK in the recipient, N107, to 28% by 52 months post diagnosis.

Variant ID.	`4133`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLhK`
Mutations	L/M N/H
Epitope Location	L6M N9H
HXB2 Location	L268M N271H
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIImGLhK in the recipient, N107, to 61% by 42 months post diagnosis, but was not seen at 52 mpd.

Variant ID.	`4134`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIIvGLhK`
Mutations	L/V N/H
Epitope Location	L6V N9H
HXB2 Location	L268V N271H
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIIvGLhK in the recipient, N107, to 8% by 42 months post diagnosis, but was not seen at 52 mpd.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.