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Displaying record number 59114

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIILGLhK   observed variant; susceptible form
KRWIImGLNK   observed variant; susceptible form
KRWIIiGLNK   observed variant
KRWIImGLhK   observed variant
KRWIIvGLhK   observed variant
Epitope Name KK10
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 5 variant(s).


Variant ID.  4130
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIILGLhK
Mutations N/H
Epitope Location N9H
HXB2 Location N271H
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence, Tetramer binding
Note CRF01_AE epitope KRWIILGLNK had mutated to the N271H variant KRWIILGLhK in the recipient, N107, at 100% by as early as 20 months post diagnosis, and was seen at 27% and 56% at 42 and 52 mpd.


Variant ID.  4131
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence, Tetramer binding
Note CRF01_AE epitope KRWIILGLNK had mutated to the L268M variant KRWIImGLNK in the recipient, N107, to 15% by 52 months post diagnosis but response to it, though reduced from WT KK10-response was detected by EliSpot as early as 20 mpd.


Variant ID.  4132
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIiGLNK
Mutations L/I
Epitope Location L6I
HXB2 Location L268I
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note CRF01_AE epitope KRWIILGLNK had mutated to the L268I variant KRWIIiGLNK in the recipient, N107, to 28% by 52 months post diagnosis.


Variant ID.  4133
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLhK
Mutations L/M N/H
Epitope Location L6M N9H
HXB2 Location L268M N271H
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIImGLhK in the recipient, N107, to 61% by 42 months post diagnosis, but was not seen at 52 mpd.


Variant ID.  4134
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIvGLhK
Mutations L/V N/H
Epitope Location L6V N9H
HXB2 Location L268V N271H
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIIvGLhK in the recipient, N107, to 8% by 42 months post diagnosis, but was not seen at 52 mpd.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


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