HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | gp160(168-176) | gp160 Epitope Map
View variants at this location |
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| Epitope |
KMQKEYALL
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Epitope Alignment | ||||||||||||||||||||||||||||
| Variants |
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| Epitope Name | KL9, 168-KMQKEYALL | |||||||||||||||||||||||||||||
| Species (MHC/HLA) | human(A*02) | |||||||||||||||||||||||||||||
Showing all: 9 variant(s).
| Variant ID. | 3280 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KkQKvhALf |
| Mutations | M/K E/V Y/H L/F |
| Epitope Location | M2K E5V Y6H L9F |
| HXB2 Location | M169K E172V Y173H L176F |
| Mutation Type | A: HLA association OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KMQKvhALf, from either strains 92TH023 or A244, bound HLA-A*0203 with IC50 = 2281 nM, but did not bind HLAs -A*0201 or -A*0207 appreciably. |
| Variant ID. | 3282 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KkQqvYALf |
| Mutations | M/K K/Q E/V L/F |
| Epitope Location | M2K K4Q E5V L9F |
| HXB2 Location | M169K K171Q E172V L176F |
| Mutation Type | A: HLA association DHB: diminished HLA binding or increased off-rate OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KkQqvYALf, from either strains 92TH023 or A244, bound HLA-A*0203 with IC50 = 25294 nM, but did not bind HLAs -A*0201 or -A*0207 appreciably. This variant was isolated from both RV144 vaccinated and -placebo CRF01_AE-infected recipients. |
| Variant ID. | 3283 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KqrKvqALf |
| Mutations | M/Q Q/R E/V Y/Q L/F |
| Epitope Location | M2Q Q3R E5V Y6Q L9F |
| HXB2 Location | M169Q Q170R E172V Y173Q L176F |
| Mutation Type | A: HLA association DHB: diminished HLA binding or increased off-rate OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KqrKvqALf, from either strains 92TH023 or A244, bound HLA-A*0203 with IC50 = 25667 nM, but did not bind HLAs -A*0201 or -A*0207 appreciably. This variant was isolated from an RV144-vaccinated CRF01_AE-infected recipient. |
| Variant ID. | 3284 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KkQKfYALf |
| Mutations | M/K E/F L/F |
| Epitope Location | M2K E5F L9F |
| HXB2 Location | M169K E172F L176F |
| Mutation Type | DHB: diminished HLA binding or increased off-rate NSF: non-susceptible form OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KkQKfYALf, from either strains 92TH023 or A244, did not bind tested HLAs -A*0203 -A*0201 or -A*0207 appreciably. This variant was isolated from both RV144-vaccinated and -placebo CRF01_AE-infected recipients. |
| Variant ID. | 3285 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KrQqvhALf |
| Mutations | M/R K/Q E/V Y/H L/F |
| Epitope Location | M2R K4Q E5V Y6H L9F |
| HXB2 Location | M169R K171Q E172V Y173H L176F |
| Mutation Type | DHB: diminished HLA binding or increased off-rate NSF: non-susceptible form OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KrQqvhALf, from either strains 92TH023 or A244, did not bind tested HLAs -A*0203 -A*0201 or -A*0207 appreciably. This variant was isolated from an RV144-vaccinated CRF01_AE-infected recipient. |
| Variant ID. | 3286 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KqQKvYALf |
| Mutations | M/Q E/V L/F |
| Epitope Location | M2Q E5V L9F |
| HXB2 Location | M169Q E172V L176F |
| Mutation Type | DHB: diminished HLA binding or increased off-rate NSF: non-susceptible form OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KqQKvYALf, from either strains 92TH023 or A244, did not bind tested HLAs -A*0203 -A*0201 or -A*0207 appreciably. This variant was isolated from both RV144-vaccinated and -placebo CRF01_AE-infected recipients. |
| Variant ID. | 3288 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | rkQqiSALf |
| Mutations | K/R M/K K/Q E/I Y/S L/F |
| Epitope Location | K1R M2K K4Q E5I Y6S L9F |
| HXB2 Location | K168R M169K K171Q E172I Y173S L176F |
| Mutation Type | A: HLA association DHB: diminished HLA binding or increased off-rate OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant rkQqiSALf, from either strains 92TH023 or A244, bound HLA-A*0201 with IC50 = 34021 nM, but did not bind HLAs -A*0203 or -A*0207 appreciably. This variant was isolated from an RV144-vaccinated CRF01_AE-infected recipient. |
| Variant ID. | 3289 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KqQnfYALf |
| Mutations | M/Q K/N E/F L/F |
| Epitope Location | M2Q K4N E5F L9F |
| HXB2 Location | M169Q K171N E172F L176F |
| Mutation Type | A: HLA association DHB: diminished HLA binding or increased off-rate OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KqQnfYALf, from either strains 92TH023 or A244, bound HLAs -A*0201 and -A*0207 with IC50 = 1768 nM and 36940 nM respectively, but did not bind HLA -A*0203 appreciably. This variant was isolated from an RV144-vaccinated CRF01_AE-infected recipient. |
| Variant ID. | 3290 |
|---|---|
| Epitope Seq. | KMQKEYALL |
| Variant Seq. | KqQqihALf |
| Mutations | M/Q K/Q E/I Y/H L/F |
| Epitope Location | M2Q K4Q E5I Y6H L9F |
| HXB2 Location | M169Q K171Q E172I Y173H L176F |
| Mutation Type | A: HLA association DHB: diminished HLA binding or increased off-rate OV: observed variant SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | CRF01_AE |
| Method | CD8 T-cell Elispot - IFNy, Peptide titration |
| Note | Subtype CRF01_AE-specific variant KqQqihALf, from either strains 92TH023 or A244, bound HLAs -A*0201 and -A*0207 with IC50 = 16306 nM and 37102 nM respectively, but did not bind HLA -A*0203 appreciably. This variant was isolated from an RV144-placebo CRF01_AE-infected recipient. |
Gartland2014 Andrew J. Gartland, Sue Li, John McNevin, Georgia D. Tomaras, Raphael Gottardo, Holly Janes, Youyi Fong, Daryl Morris, Daniel E. Geraghty, Gustavo H. Kijak, Paul T. Edlefsen, Nicole Frahm, Brendan B. Larsen, Sodsai Tovanabutra, Eric Sanders-Buell, Allan C. deCamp, Craig A. Magaret, Hasan Ahmed, Jodie P. Goodridge, Lennie Chen, Philip Konopa, Snehal Nariya, Julia N. Stoddard, Kim Wong, Hong Zhao, Wenjie Deng, Brandon S. Maust, Meera Bose, Shana Howell, Adam Bates, Michelle Lazzaro, Annemarie O'Sullivan, Esther Lei, Andrea Bradfield, Grace Ibitamuno, Vatcharain Assawadarachai, Robert J. O'Connell, Mark S. deSouza, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Merlin L. Robb, John Sidney, Alessandro Sette, Susan Zolla-Pazner, David Montefiori, M. Juliana McElrath, James I. Mullins, Jerome H. Kim, Peter B. Gilbert, and Tomer Hertz. Analysis of HLA A*02 Association with Vaccine Efficacy in The RV144 HIV-1 Vaccine Trial. J. Virol., 88(15):8242-8255, Aug 2014. PubMed ID: 24829343. Show all entries for this paper.