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Displaying record number 59091

HXB2 Location gp160(61-69) gp160 Epitope Map
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YETEVHNVW

`YgTEVHNVW`		diminished response
`YdTEVHNVW`		diminished response
`YdTEaHNVW`		diminished response

Species (MHC/HLA) human(B*18:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`3265`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YgTEVHNVW`
Mutations	E/G
Epitope Location	E2G
HXB2 Location	E62G
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	Peptide titration
Note	Ratio of EliSpot peptide titration of this mutant to original epitope EC₅₀ratio = 22, suggesting partial escape.

Variant ID.	`3266`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEVHNVW`
Mutations	E/D
Epitope Location	E2D
HXB2 Location	E62D
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	Peptide titration
Note	Ratio of EliSpot peptide titration of this mutant to original epitope EC₅₀ratio = 13, suggesting partial escape.

Variant ID.	`3267`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEaHNVW`
Mutations	E/D V/A
Epitope Location	E2D V5A
HXB2 Location	E62D V65A
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	Peptide titration
Note	Ratio of EliSpot peptide titration of this mutant to original epitope EC₅₀ratio = >83, suggesting partial escape.

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.