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Found 1 matching record:

Displaying record number 59091

HXB2 Location  gp160(61-69)   gp160 Epitope Map
View variants at this location
Epitope YETEVHNVW   Epitope Alignment
Variants
YgTEVHNVW   diminished response
YdTEVHNVW   diminished response
YdTEaHNVW   diminished response
Species (MHC/HLA human(B*18:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3265
Epitope Seq.  YETEVHNVW
Variant Seq.  YgTEVHNVW
Mutations E/G
Epitope Location E2G
HXB2 Location E62G
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Peptide titration
Note Ratio of EliSpot peptide titration of this mutant to original epitope EC50ratio = 22, suggesting partial escape.


Variant ID.  3266
Epitope Seq.  YETEVHNVW
Variant Seq.  YdTEVHNVW
Mutations E/D
Epitope Location E2D
HXB2 Location E62D
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Peptide titration
Note Ratio of EliSpot peptide titration of this mutant to original epitope EC50ratio = 13, suggesting partial escape.


Variant ID.  3267
Epitope Seq.  YETEVHNVW
Variant Seq.  YdTEaHNVW
Mutations E/D V/A
Epitope Location E2D V5A
HXB2 Location E62D V65A
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Peptide titration
Note Ratio of EliSpot peptide titration of this mutant to original epitope EC50ratio = >83, suggesting partial escape.

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


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