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Found 1 matching record:

Displaying record number 59083

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   diminished response
TAFTIPSr   diminished response
TAFTIPSv   diminished response
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3250
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Peptide titration
Note Ratio of EliSpot peptide titration of this mutant to original epitope EC50ratio = >100, suggesting partial escape.


Variant ID.  3251
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Peptide titration
Note Ratio of EliSpot peptide titration of this mutant to original epitope, EC50ratio = >100, suggesting partial escape.


Variant ID.  3252
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Peptide titration
Note Ratio of EliSpot peptide titration of this mutant to original epitope EC50ratio = >100, suggesting partial escape.

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


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