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Found 1 matching record:

Displaying record number 59058

HXB2 Location  Nef(64-74)   Nef Epitope Map
View variants at this location
Epitope EEVGFPVKPQV   Epitope Alignment
Variants
dEVGFPVKPQV   diminished response; escape documented in this paper
dEVGFPVrPQV   diminished response; escape documented in this paper
gEVGFPVrPQV   susceptible form
Epitope Name Nef 64-74
Species (MHC/HLA human(B*45:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3228
Epitope Seq.  EEVGFPVKPQV
Variant Seq.  dEVGFPVKPQV
Mutations E/D
Epitope Location E1D
HXB2 Location E64D
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Variant dEVGFPVKPQV had a calculated time to escape of 8 days.


Variant ID.  3229
Epitope Seq.  EEVGFPVKPQV
Variant Seq.  dEVGFPVrPQV
Mutations E/D K/R
Epitope Location E1D K8R
HXB2 Location E64D K71R
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Variant dEVGFPVrPQV had a calculated time to escape of 8 days.


Variant ID.  3230
Epitope Seq.  EEVGFPVKPQV
Variant Seq.  gEVGFPVrPQV
Mutations E/G K/R
Epitope Location E1G K8R
HXB2 Location E64G K71R
Mutation Type SF: susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant gEVGFPVrPQV had a calculated time to escape of 8 days.

References

Liu2013a Michael K. P. Liu, Natalie Hawkins, Adam J. Ritchie, Vitaly V. Ganusov, Victoria Whale, Simon Brackenridge, Hui Li, Jeffrey W. Pavlicek, Fangping Cai, Melissa Rose-Abrahams, Florette Treurnicht, Peter Hraber, Catherine Riou, Clive Gray, Guido Ferrari, Rachel Tanner, Li-Hua Ping, Jeffrey A. Anderson, Ronald Swanstrom, CHAVI Core B, Myron Cohen, Salim S. Abdool Karim, Barton Haynes, Persephone Borrow, Alan S. Perelson, George M. Shaw, Beatrice H. Hahn, Carolyn Williamson, Bette T. Korber, Feng Gao, Steve Self, Andrew McMichael, and Nilu Goonetilleke. Vertical T Cell Immunodominance and Epitope Entropy Determine HIV-1 Escape. J. Clin. Invest., 123(1):380-393, 2 Jan 2013. PubMed ID: 23221345. Show all entries for this paper.


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