HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Nef(128-137) | Nef Epitope Map
View variants at this location |
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| Epitope |
TPGPGIRYPL
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | TL10-Nef | |||||
| Species (MHC/HLA) | human(B*07:02) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3223 |
|---|---|
| Epitope Seq. | TPGPGIRYPL |
| Variant Seq. | TPGPGvRYPL |
| Mutations | I/V |
| Epitope Location | I6V |
| HXB2 Location | I133V |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | C |
| Method | HLA binding |
| Note | Variant TL10-Nef, TPGPGvRYPL, a C-clade Nef epitope was targeted by C-clade infected subjects more robustly than the B-clade variant TL10. The affinity of TL10 to B*0702 was Kd = 27 nM. Clade-C TL10 is contained within OLP84, NYTPGPGvRYPLTFGWCF. |
Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.