HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 59047

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGIRYPL   Epitope Alignment
TPGPGvRYPL   subtype-specific susceptible form
Epitope Name TL10-Nef
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.  3223
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRYPL
Mutations I/V
Epitope Location I6V
HXB2 Location I133V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method HLA binding
Note Variant TL10-Nef, TPGPGvRYPL, a C-clade Nef epitope was targeted by C-clade infected subjects more robustly than the B-clade variant TL10. The affinity of TL10 to B*0702 was Kd = 27 nM. Clade-C TL10 is contained within OLP84, NYTPGPGvRYPLTFGWCF.


Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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