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Displaying record number 59014

HXB2 Location Gag(263-272) Gag Epitope Map
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KRWIILGLNK

`KRWIImGLNK`		susceptible form
`KkWIILGLNK`		escape documented in this paper; literature escape; non-susceptible form

Epitope Name KK10

Species (MHC/HLA) human(B*27:05)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3211`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	SF: susceptible form
Method	Chromium-release assay
Note	Variant KRWIImGLNK was recognized equally well by KK10-specific CTL. Structurally the TCR-KK10 and TCR-Leu268Met variant were identical.

Variant ID.	`3212`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KkWIILGLNK`
Mutations	R/K
Epitope Location	R2K
HXB2 Location	R264K
Mutation Type	E: escape documented in this paper LE: literature escape NSF: non-susceptible form
Method	Chromium-release assay
Note	Variant KkWIILGLNK was not recognized by KK10-specific CTL and therefore an escape. This epitope variation was more slowly acquired.

References

Ladell2013 Kristin Ladell, Masao Hashimoto, Maria Candela Iglesias, Pascal G. Wilmann, James E. McLaren, Stéphanie Gras, Takayuki Chikata, Nozomi Kuse, Solène Fastenackels, Emma Gostick, John S. Bridgeman, Vanessa Venturi, Zaïna Aït Arkoub, Henri Agut, David J. van Bockel, Jorge R. Almeida, Daniel C. Douek, Laurence Meyer, Alain Venet, Masafumi Takiguchi, Jamie Rossjohn, David A. Price, and Victor Appay. A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells. Immunity, 38(3):425-436, 21 Mar 2013. PubMed ID: 23521884. Show all entries for this paper.