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Found 1 matching record:

Displaying record number 59014

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   susceptible form
KkWIILGLNK   escape documented in this paper; literature escape; non-susceptible form
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3211
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Variant KRWIImGLNK was recognized equally well by KK10-specific CTL. Structurally the TCR-KK10 and TCR-Leu268Met variant were identical.


Variant ID.  3212
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type E: escape documented in this paper
LE: literature escape
NSF: non-susceptible form
Method Chromium-release assay
Note Variant KkWIILGLNK was not recognized by KK10-specific CTL and therefore an escape. This epitope variation was more slowly acquired.

References

Ladell2013 Kristin Ladell, Masao Hashimoto, Maria Candela Iglesias, Pascal G. Wilmann, James E. McLaren, Stéphanie Gras, Takayuki Chikata, Nozomi Kuse, Solène Fastenackels, Emma Gostick, John S. Bridgeman, Vanessa Venturi, Zaïna Aït Arkoub, Henri Agut, David J. van Bockel, Jorge R. Almeida, Daniel C. Douek, Laurence Meyer, Alain Venet, Masafumi Takiguchi, Jamie Rossjohn, David A. Price, and Victor Appay. A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells. Immunity, 38(3):425-436, 21 Mar 2013. PubMed ID: 23521884. Show all entries for this paper.


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