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Found 1 matching record:

Displaying record number 58841

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   observed variant
QASQtVKNW   observed variant
QASkEVKNW   observed variant
Epitope Name QW9
Species (MHC/HLA human(B*5701)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3185
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E311D
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay
Note Epitope mutation, E|QASQdVKNW|M, was seen for QW9 by the first sampling 13 weeks post-infection in P1 who carried HLA alleles A*0101,A*0301,B*2705,B*5701; and by 75 weeks post-infection in P3 who carried HLA alleles A*2402,A*3201,B*4002,B*5701.


Variant ID.  3186
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQtVKNW
Mutations E/T
Epitope Location E5T
HXB2 Location E311T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay
Note Epitope mutation E312T, E|QASQtVKNW|M, was seen for QW9 by the first sampling 18 weeks post-infection in P2 who carried HLA alleles A*0101,A*2402,B*4002,B*5701.


Variant ID.  3187
Epitope Seq.  QASQEVKNW
Variant Seq.  QASkEVKNW
Mutations Q/K
Epitope Location Q4K
HXB2 Location Q310K
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay
Note Minor (4.5%) epitope variation E312K, E|QASkEVKNW|M, was seen for QW9 at 60 weeks post-infection in P4 who carried HLA alleles A*0101,A*0201,B*5101,B*5701.

References

Norstrom2012 Melissa M. Norström, Marcus Buggert, Johanna Tauriainen, Wendy Hartogensis, Mattia C. Prosperi, Mark A. Wallet, Frederick M. Hecht, Marco Salemi, and Annika C. Karlsson. Combination of Immune and Viral Factors Distinguishes Low-Risk Versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects. J. Virol., 86(18):9802-9816, Sep 2012. PubMed ID: 22761389. Show all entries for this paper.


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