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Found 1 matching record:

Displaying record number 58806

HXB2 Location  Nef(92-100)   Nef Epitope Map
View variants at this location
Epitope KEKGGLEGL   Epitope Alignment
Variants
KEKGGLdGL   subtype-specific non-susceptible form; subtype-specific susceptible form
Epitope Name KL9
Species (MHC/HLA human(B*40)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3145
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLdGL
Mutations E/D
Epitope Location E7D
HXB2 Location E98D
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype C, CRF01_AE, D, F
Variant Subtype A, B, G, H
Method CD8 T-cell Elispot - IFNy
Note The same KL9-7D sequence from different subtypes (clades A, B, G and H), was recognized to different extents; just as KL9 from various clades was recognized to varying extents. Both KL9 and KL9-D were found to have the same functional avidity.

References

Culshaw2012 Abigail Culshaw, Tao Dong, and Sarah Louise Rowland-Jones. A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes. J. Acquir. Immune Defic. Syndr., 59(4):335-339, 1 Apr 2012. PubMed ID: 22217677. Show all entries for this paper.


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