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Displaying record number 58806

HXB2 Location Nef(92-100) Nef Epitope Map
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Epitope

KEKGGLEGL

Epitope Alignment

Variants

KEKGGLdGL subtype-specific non-susceptible form; subtype-specific susceptible form

Epitope Name KL9

Species (MHC/HLA) human(B*40)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3145`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KEKGGLdGL`
Mutations	E/D
Epitope Location	E7D
HXB2 Location	E98D
Mutation Type	SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form
Epitope Subtype	C, CRF01_AE, D, F
Variant Subtype	A, B, G, H
Method	CD8 T-cell Elispot - IFNy
Note	The same KL9-7D sequence from different subtypes (clades A, B, G and H), was recognized to different extents; just as KL9 from various clades was recognized to varying extents. Both KL9 and KL9-D were found to have the same functional avidity.

References

Culshaw2012 Abigail Culshaw, Tao Dong, and Sarah Louise Rowland-Jones. A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes. J. Acquir. Immune Defic. Syndr., 59(4):335-339, 1 Apr 2012. PubMed ID: 22217677. Show all entries for this paper.