HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 58707

HXB2 Location  Pol(982-990)   Pol Epitope Map
View variants at this location
Epitope IIKDYGKQM   Epitope Alignment
IIxDYGKQM   escape documented in this paper
Epitope Name Int-IM9
Species (MHC/HLA human(B*4201)

Variant Details

Showing all: 1 variant(s).

Variant ID.  3116
Epitope Seq.  IIKDYGKQM
Variant Seq.  IIxDYGKQM
Mutations K/X
Epitope Location K3X
HXB2 Location K984X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Novel epitope, IM9 does accumulate mutations at position 3, IIxDYGKQM. The authors designate this variant as an escape when presented by HLA-B*4201.


Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.

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