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Found 1 matching record:

Displaying record number 58674

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
{x}ISPRTLNAW   calculated escape
xSPRTLNAW   calculated escape
Epitope Name ISW9
Species (MHC/HLA human(B*57:01, B*57:02, B*57:03, B*58:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3093
Epitope Seq.  {A}ISPRTLNAW
Variant Seq.  {x}ISPRTLNAW
Mutations A/X
Epitope Location A-1X
HXB2 Location A146X
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note ISW9 escapes at A146X, {x}ISPRTLNAW, are seen in ˜100% of HLA-B*5703 and -B*5702 positive subjects.


Variant ID.  3094
Epitope Seq.  ISPRTLNAW
Variant Seq.  xSPRTLNAW
Mutations I/X
Epitope Location I2X
HXB2 Location I148X
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note ISW9 escapes at I147X, xSPRTLNAW, are seen in >75% of HLA-B*5703 and -B*5702 positive subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


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