HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 58651

HXB2 Location  Gag(253-262)   Gag Epitope Map
View variants at this location
Epitope NPPIPVGEIY   Epitope Alignment
Variants
NPPIPVGdIY   susceptible form; subtype-specific susceptible form
Epitope Name NY10, NY10-260E
Species (MHC/HLA human(B*3501)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3082
Epitope Seq.  NPPIPVGEIY
Variant Seq.  NPPIPVGdIY
Mutations E/D
Epitope Location E8D
HXB2 Location E260D
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding, Intracellular cytokine staining, Tetramer binding
Note The B clade variant, NPPIPVGdIY, is also the major C clade form of epitope NY10. This NY10-260D variant binds to HLA-B*3105 10x better than the Clade B wt and is 3x more stable.

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health