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Found 1 matching record:

Displaying record number 58646

HXB2 Location  gp160(813-822)   gp160 Epitope Map
View variants at this location
Epitope SLLNATDIAV   Epitope Alignment
Variants
SLLNATaIAV   susceptible form
nLLNtiaIAV   diminished response; non-susceptible form
Epitope Name Env814-823
Species (MHC/HLA human(A*0201)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3074
Epitope Seq.  SLLNATDIAV
Variant Seq.  SLLNATaIAV
Mutations D/A
Epitope Location D7A
HXB2 Location D820A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay, Sequence
Note This variant was found to be autologous in 2/5 subjects and surprisingly was recognized at lower concentrations [1 log lower] for target lysis.


Variant ID.  3075
Epitope Seq.  SLLNATDIAV
Variant Seq.  nLLNtiaIAV
Mutations S/N A/T T/I D/A
Epitope Location S1N A5T T6I D7A
HXB2 Location S814N A818T T819I D820A
Mutation Type DR: diminished response
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay, Sequence
Note This variant was found to be autologous in 2/5 subjects and abrogated all CTL target lysis.

References

Dupuis1995 M. Dupuis, S. K. Kundu, and T. C. Merigan. Characterization of HLA-A*0201-Restricted Cytotoxic T Cell Epitopes in Conserved Regions of the HIV Type 1 gp160 Protein. J. Immunol., 155:2232-2239, 1995. Five HLA-A2 HIV-1 seropositive HIV-1 MN rec gp160 vaccinees had their CTL activity assessed using peptides known to bind with high affinity to HLA-A*0201. Four of the patients had specific CTL activity for a minimum of at least three epitopes, thus the response appears heterogeneous. One of the four peptides was confirmed to be HLA A2 restricted. Epitopes were highly conserved. PubMed ID: 7543542. Show all entries for this paper.


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