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Displaying record number 58601

HXB2 Location  Pol(829-836)   Pol Epitope Map
View variants at this location
Epitope HTDNGSNF   Epitope Alignment
Variants
HTDNGrNF   HLA association; replicative capacity reduced
{e...}HTDNGrNF   HLA association; replicative capacity is not abrogated; susceptible form
HTDNGpNF   observed variant
Epitope Name HF8
Species (MHC/HLA human(Cw*05)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3076
Epitope Seq.  HTDNGSNF
Variant Seq.  HTDNGrNF
Mutations S/R
Epitope Location S6R
HXB2 Location S834R
Mutation Type A: HLA association
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Relative replication capacity assay, Sequence
Note The S119R polymorphism exhibited an ˜35% lower RC than parental NL4-3 in recombinants carrying mutant, HTDNGrNF.


Variant ID.  3077
Epitope Seq.  {A...}HTDNGSNF
Variant Seq.  {e...}HTDNGrNF
Mutations A/E S/R
Epitope Location A-28E S6R
HXB2 Location A806E S834R
Mutation Type A: HLA association
RCOK: replicative capacity is not abrogated
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Relative replication capacity assay, Sequence
Note Double A91E, S119R mutant recombinants exhibited an RC comparable to wild-type RC, confirming A91E as an upstream secondary compensatory mutation for S119R HF8. No A91E mutation alone occurred naturally in any patient in this study, as it was always associated with S119R.


Variant ID.  3078
Epitope Seq.  HTDNGSNF
Variant Seq.  HTDNGpNF
Mutations S/P
Epitope Location S6P
HXB2 Location S834P
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note The S119P variant, HTDNGpNF, was seen in some C*05-carrying patients.

References

Brockman2012 Mark A. Brockman, Denis R. Chopera, Alex Olvera, Chanson J. Brumme, Jennifer Sela, Tristan J. Markle, Eric Martin, Jonathan M. Carlson, Anh Q. Le, Rachel McGovern, Peter K. Cheung, Anthony D. Kelleher, Heiko Jessen, Martin Markowitz, Eric Rosenberg, Nicole Frahm, Jorge Sanchez, Simon Mallal, Mina John, P. Richard Harrigan, David Heckerman, Christian Brander, Bruce D. Walker, and Zabrina L. Brumme. Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity. J. Virol., 86(12):6913-6923, Jun 2012. PubMed ID: 22496233. Show all entries for this paper.


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