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Found 1 matching record:

Displaying record number 58600

HXB2 Location  Gag(253-262)   Gag Epitope Map
View variants at this location
Epitope NPPIPVGDIY   Epitope Alignment
Variants
NPPIPVGeIY   diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; subtype-specific non-susceptible form
Epitope Name NY10, NY10-260D
Species (MHC/HLA human(B*3501)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3081
Epitope Seq.  NPPIPVGDIY
Variant Seq.  NPPIPVGeIY
Mutations D/E
Epitope Location D8E
HXB2 Location D260E
Mutation Type DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Intracellular cytokine staining, Sequence, Tetramer binding
Note The C clade variant, NPPIPVGeIY, is also the major B clade form of epitope NY10. This NY10-260E variant binds to HLA-B*3105 10x less well than the wt and is 3x less stable.

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


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