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Displaying record number 58280

HXB2 Location Gag(263-272) Gag Epitope Map
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KRWIILGLNK

`KRWIImGLNK`		literature escape
`KRWIvLGLNK`		literature escape

Epitope Name KK10

Species (MHC/HLA) human(B*27)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2861`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	LE: literature escape
Epitope Subtype	B
Variant Subtype	B
Method	Intracellular cytokine staining
Note	KRWIImGLNK was one of 2 KK10 sequence variants cross-recognized by subdominant clonotypes. This variant had similar results as those with consensus stimulation.

Variant ID.	`2862`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIvLGLNK`
Mutations	I/V
Epitope Location	I5V
HXB2 Location	I267V
Mutation Type	LE: literature escape
Epitope Subtype	B
Variant Subtype	B
Method	Intracellular cytokine staining
Note	KRWIvLGLNK was one of 2 KK10 sequence variants cross-recognized by subdominant clonotypes. This variant stimulated the dominant clonotype, TRBV12, to reach lower cytokine production than that by subdominant clonotypes which upon recognizing this variant peptide produced their highest levels of cytokine TNF-alpha and IFN-gamma.

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.