HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 58245

HXB2 Location  Nef(92-100)   Nef Epitope Map
View variants at this location
Epitope KEKGGLEGL   Epitope Alignment
KEKGGLEGm   inferred escape
Species (MHC/HLA human(B*40:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.  2842
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEGm
Mutations L/M
Epitope Location L9M
HXB2 Location L100M
Mutation Type IE: inferred escape
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 16/21 and 8/10 sequences of epitope KEKGGLEGL varied at 552 and 718 DFOSx to KEKGGLEGm. Position 100 in the epitope is marked as being under selection to vary.


Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.

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