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Displaying record number 58169

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
Variants
tPQVPLRPMTY   escape documented in this paper
tPQVPLRPMTf   escape documented in this paper
Epitope Name RY11
Species (MHC/HLA human(B35)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2779
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  tPQVPLRPMTY
Mutations R/T
Epitope Location R1T
HXB2 Location R71T
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Cytotoxicity assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note RPQVPLRPMTY-specific CTLs had toxicity toward HIV-infected macrophages, but failed to kill R71T mutant virus-infected cells.


Variant ID.  2780
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  tPQVPLRPMTf
Mutations R/T Y/F
Epitope Location R1T Y11F
HXB2 Location R71T Y81F
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Cytotoxicity assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note RPQVPLRPMTY-specific CTLs had toxicity toward HIV-infected macrophages, but failed to kill R71T/Y81F mutant virus-infected cells.

References

Mwimanzi2011 Philip Mwimanzi, Zafrul Hasan, Ranya Hassan, Shinya Suzu, Masafumi Takiguchi, and Takamasa Ueno. Effects of Naturally-Arising HIV Nef Mutations on Cytotoxic T Lymphocyte Recognition and Nef's Functionality in Primary Macrophages. Retrovirology, 8:50, 2011. PubMed ID: 21696586. Show all entries for this paper.


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