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Found 1 matching record:

Displaying record number 58151

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSv   diminished response
TAFTIPSr   diminished response
TAFTIPSt   diminished response
Epitope Name TI8
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2739
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.


Variant ID.  2740
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.


Variant ID.  2741
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


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