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Displaying record number 58146

HXB2 Location  Tat(30-37)   Tat Epitope Map
View variants at this location
Epitope CCFHCQVC   Epitope Alignment
Variants
CCFHCQsC   escape documented in this paper
CClHCQVC   escape documented in this paper
Epitope Name CC8
Species (MHC/HLA human(C*12:03)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2727
Epitope Seq.  CCFHCQVC
Variant Seq.  CCFHCQsC
Mutations V/S
Epitope Location V7S
HXB2 Location V36S
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant CCFHCQsC arose early in infection, then disappeared, while CClHCQVC dominated by 200 days post-infection. Both variants were associated with loss of EliSpot response to the epitope.


Variant ID.  2728
Epitope Seq.  CCFHCQVC
Variant Seq.  CClHCQVC
Mutations F/L
Epitope Location F3L
HXB2 Location F32L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant CCFHCQsC arose early in infection, then disappeared, while CClHCQVC dominated by 200 days post-infection. Both variants were associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


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