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Found 1 matching record:

Displaying record number 58009

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KgWIILGLNK   HLA association; processing
KkWIImGLNK   HLA association; processing
KRWIImGLNK   HLA association; processing
KkWIImGLhK   HLA association; processing
Epitope Name KK10
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 4 variant(s).


Variant ID.  2701
Epitope Seq.  KRWIILGLNK
Variant Seq.  KgWIILGLNK
Mutations R/G
Epitope Location R2G
HXB2 Location R264G
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.


Variant ID.  2702
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.


Variant ID.  2703
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.


Variant ID.  2704
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLhK
Mutations R/K L/M N/H
Epitope Location R2K L6M N9H
HXB2 Location R264K L268M N271H
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


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