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Found 1 matching record:

Displaying record number 57958

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGIRYPL   Epitope Alignment
Variants
TPGPGvRYPL   susceptible form
Epitope Name TL10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2689
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRYPL
Mutations I/V
Epitope Location I6V
HXB2 Location I133V
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note TPGPGIRYPL underwent adaptation to neo-epitope TPGPGvRYPL. 6 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


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