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Found 1 matching record:

Displaying record number 57955

HXB2 Location  Pol(838-847)   Pol Epitope Map
View variants at this location
Epitope STTVKAACWW   Epitope Alignment
Variants
STaVKAACWW   escape documented in this paper; literature escape
SnTVKAACWW   escape documented in this paper; literature escape
Epitope Name SW10
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2685
Epitope Seq.  STTVKAACWW
Variant Seq.  STaVKAACWW
Mutations T/A
Epitope Location T3A
HXB2 Location T840A
Mutation Type E: escape documented in this paper
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note STTVKAACWW underwent classical escape, with adapted forms STaVKAACWW and SnTVKAACWW having abrogated EliSpot responses.


Variant ID.  2686
Epitope Seq.  STTVKAACWW
Variant Seq.  SnTVKAACWW
Mutations T/N
Epitope Location T2N
HXB2 Location T839N
Mutation Type E: escape documented in this paper
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note STTVKAACWW underwent classical escape, with adapted forms STaVKAACWW and SnTVKAACWW having abrogated EliSpot responses.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


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