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Found 1 matching record:

Displaying record number 57953

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIIMGLNK   escape documented in this paper; TCR related mutation
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2668
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIMGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy, TCR binding
Note The L6M mutant was associated with lower antigen sensitivity. The early-arising L6M mutation enables the virus to avoid recognition by effective CD8+ T-cell clonotypes.

References

Iglesias2011 Maria Candela Iglesias, Jorge R. Almeida, Solène Fastenackels, David J. van Bockel, Masao Hashimoto, Vanessa Venturi, Emma Gostick, Alejandra Urrutia, Linda Wooldridge, Mathew Clement, Stéphanie Gras, Pascal G. Wilmann, Brigitte Autran, Arnaud Moris, Jamie Rossjohn, Miles P. Davenport, Masafumi Takiguchi, Christian Brander, Daniel C. Douek, Anthony D. Kelleher, David A. Price, and Victor Appay. Escape from Highly Effective Public CD8+ T-Cell Clonotypes by HIV. Blood, 118(8):2138-2149, 25 Aug 2011. PubMed ID: 21734237. Show all entries for this paper.


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