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Displaying record number 57953

HXB2 Location Gag(263-272) Gag Epitope Map
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Epitope

KRWIILGLNK

Epitope Alignment

Variants

KRWIIMGLNK escape documented in this paper; TCR related mutation

Epitope Name KK10

Species (MHC/HLA) human(B*27:05)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2668`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIIMGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	CD8 T-cell Elispot - IFNy, TCR binding
Note	The L6M mutant was associated with lower antigen sensitivity. The early-arising L6M mutation enables the virus to avoid recognition by effective CD8+ T-cell clonotypes.

References

Iglesias2011 Maria Candela Iglesias, Jorge R. Almeida, Solène Fastenackels, David J. van Bockel, Masao Hashimoto, Vanessa Venturi, Emma Gostick, Alejandra Urrutia, Linda Wooldridge, Mathew Clement, Stéphanie Gras, Pascal G. Wilmann, Brigitte Autran, Arnaud Moris, Jamie Rossjohn, Miles P. Davenport, Masafumi Takiguchi, Christian Brander, Daniel C. Douek, Anthony D. Kelleher, David A. Price, and Victor Appay. Escape from Highly Effective Public CD8+ T-Cell Clonotypes by HIV. Blood, 118(8):2138-2149, 25 Aug 2011. PubMed ID: 21734237. Show all entries for this paper.