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Found 1 matching record:

Displaying record number 57921

HXB2 Location  gp160(435-443)   gp160 Epitope Map
View variants at this location
Epitope YAPPISGQI   Epitope Alignment
Variants
YAPPIaGnI   HLA association; observed variant
YAPPIrGQI   HLA association; observed variant
YAPPIqGvI   HLA association; observed variant
YAPPIeGnI   HLA association; observed variant
YAPPISGrI   HLA association; observed variant
YAPPIeGlI   HLA association; observed variant
YAPPIpGvI   HLA association; observed variant
YAPPIaGQI   HLA association; observed variant
YAPPIkGQI   HLA association; observed variant
YAPPIkGnI   HLA association; observed variant
YAPPIeGQI   HLA association; observed variant
YAPPIqGiI   HLA association; observed variant
YAPPIkGsI   HLA association; observed variant
YAPPIrGiI   HLA association; observed variant
YAPPIpGiI   HLA association; observed variant
YAPPIaGkI   HLA association; observed variant
YAPPIrGvI   HLA association; observed variant
YAPPIeGiI   HLA association; observed variant
YAPPIpGeI   HLA association; observed variant
YAPPIrGnl   HLA association; observed variant
YAPPIkGnl   HLA association; observed variant
YAPPISGtI   HLA association; observed variant
Epitope Name p41A
Species (MHC/HLA macaque(Mamu-A*01)

Variant Details

Showing all: 22 variant(s).


Variant ID.  2754
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIaGnI
Mutations S/A Q/N
Epitope Location S6A Q8N
HXB2 Location S440A Q442N
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype C, G, J
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 1, YAPPIaGnI, binds Mamu-A*01 and is found at a frequency of 15.93% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 23.95 nM was required to inhibit binding of 50% radiolabeled p41A. Since this peptide has a low IC50 value, it was used for tetramer binding studies that showed cross-recognition with p41A by a small population of CTL from monkey 3096 and a large population of CTL from monkey 8998.


Variant ID.  2755
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIrGQI
Mutations S/R
Epitope Location S6R
HXB2 Location S440R
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 2, YAPPIrGQI, binds Mamu-A*01 and is found at a frequency of 9.69% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 563.3 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2756
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIqGvI
Mutations S/Q Q/V
Epitope Location S6Q Q8V
HXB2 Location S440Q Q442V
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype A, CRF02_AG
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 3, YAPPIqGvI, binds Mamu-A*01 and is found at a frequency of 3.19% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 34.72 nM was required to inhibit binding of 50% radiolabeled p41A. Since this peptide has a low IC50 value, it was used for tetramer binding studied that showed cross-recognition with p41A by small populations of CTL from monkeys 3096 and 8998.


Variant ID.  2757
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIeGnI
Mutations S/E Q/N
Epitope Location S6E Q8N
HXB2 Location S440E Q442N
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 4, YAPPIeGnI, binds Mamu-A*01 and is found at a frequency of 5.16% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 573.7 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2758
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPISGrI
Mutations Q/R
Epitope Location Q8R
HXB2 Location Q442R
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype CRF01_AE
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 5, YAPPISGrI, binds Mamu-A*01 and is found at a frequency of 1.08% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 7.04 nM was required to inhibit binding of 50% radiolabeled p41A. Since this peptide has a low IC50 value, it was used for tetramer binding studies that showed cross-recognition with p41A by a small population of CTL from monkey 3096; but no cross-recognition was seen by CTL from monkey 8998.


Variant ID.  2759
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIeGlI
Mutations S/E Q/L
Epitope Location S6E Q8L
HXB2 Location S440E Q442L
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype D
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 6, YAPPIeGlI, binds Mamu-A*01 and is found at a frequency of 1.93% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 19.78 nM was required to inhibit binding of 50% radiolabeled p41A. Since this peptide has a low IC50 value, it was used for tetramer binding studies that showed no cross-recognition with p41A by CTL from monkeys 3096 and 8998.


Variant ID.  2760
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIpGvI
Mutations S/P Q/V
Epitope Location S6P Q8V
HXB2 Location S440P Q442V
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 7, YAPPIpGvI, binds Mamu-A*01 and is found at a frequency of 2.06% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 478.3 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2761
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIaGQI
Mutations S/A
Epitope Location S6A
HXB2 Location S440A
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype D
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 8, YAPPIaGQI, binds Mamu-A*01 and is found at a frequency of 1.3% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 11.7 nM was required to inhibit binding of 50% radiolabeled p41A. Since this peptide has a low IC50 value, it was used for tetramer binding studies that showed cross-recognition with p41A by large populations of CTL from monkeys 3096 and 8998.


Variant ID.  2762
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIkGQI
Mutations S/K
Epitope Location S6K
HXB2 Location S440K
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 9, YAPPIkGQI, binds Mamu-A*01 and is found at a frequency of 2.56% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 643.5 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2763
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIkGnI
Mutations S/K Q/N
Epitope Location S6K Q8N
HXB2 Location S440K Q442N
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 10, YAPPIkGnI, binds Mamu-A*01 and is found at a frequency of 1.75% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 504.1 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2765
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIeGQI
Mutations S/E
Epitope Location S6E
HXB2 Location S440E
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 11, YAPPIeGQI, binds Mamu-A*01 and is found at a frequency of 1.7% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 326.6 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2766
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIqGiI
Mutations S/Q Q/I
Epitope Location S6Q Q8I
HXB2 Location S440Q Q442I
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype A, B, C, CRF02_AG
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 12, YAPPIqGiI, binds Mamu-A*01 and is found at a frequency of 1.08% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 30.58 nM was required to inhibit binding of 50% radiolabeled p41A. Since this peptide has a low IC50 value, it was used for tetramer binding studies that showed no cross-recognition with p41A by CTL from monkey 3096; but a small population of CTL from monkey 8998 did cross-recognize this Variant 12 with p41A.


Variant ID.  2767
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIkGsI
Mutations S/K Q/S
Epitope Location S6K Q8S
HXB2 Location S440K Q442S
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 13, YAPPIkGsI, binds Mamu-A*01 and is found at a frequency of 0.36% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 421.5 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2768
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIrGiI
Mutations S/R Q/I
Epitope Location S6R Q8I
HXB2 Location S440R Q442I
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 14, YAPPIrGiI, binds Mamu-A*01 and is found at a frequency of 0.94% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 221.1 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2769
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIpGiI
Mutations S/P Q/I
Epitope Location S6P Q8I
HXB2 Location S440P Q442I
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 15, YAPPIpGiI, binds Mamu-A*01 and is found at a frequency of 1.08% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 493.1 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2770
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIaGkI
Mutations S/A Q/K
Epitope Location S6A Q8K
HXB2 Location S440A Q442K
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype F2
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 16, YAPPIaGkI, binds Mamu-A*01 and is found at a frequency of 1.21% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 26.18 nM was required to inhibit binding of 50% radiolabeled p41A. Since this peptide has a low IC50 value, it was used for tetramer binding studies that showed cross-recognition with p41A by small populations of CTL from monkeys 3096 and 8998.


Variant ID.  2771
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIrGvI
Mutations S/R Q/V
Epitope Location S6R Q8V
HXB2 Location S440R Q442V
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 17, YAPPIrGvI, binds Mamu-A*01 and is found at a frequency of 0.85% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 143.3 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2772
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIeGiI
Mutations S/E Q/I
Epitope Location S6E Q8I
HXB2 Location S440E Q442I
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 20, YAPPIeGiI, binds Mamu-A*01 and is found at a frequency of 0.85% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 299.7 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2773
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIpGeI
Mutations S/P Q/E
Epitope Location S6P Q8E
HXB2 Location S440P Q442E
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 21, YAPPIpGeI, binds Mamu-A*01 and is found at a frequency of 0.54% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 96.11 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2774
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIrGnl
Mutations S/R Q/N I/L
Epitope Location S6R Q8N I9L
HXB2 Location S440R Q442N I443L
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 17, YAPPIrGnl, binds Mamu-A*01 and is found at a frequency of 0.49% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 287.5 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2775
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPIkGnl
Mutations S/K Q/N I/L
Epitope Location S6K Q8N I9L
HXB2 Location S440K Q442N I443L
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 18, YAPPIkGnl, binds Mamu-A*01 and is found at a frequency of 0.45% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses. When used as cold competitor, 471.3 nM was required to inhibit binding of 50% radiolabeled p41A.


Variant ID.  2776
Epitope Seq.  YAPPISGQI
Variant Seq.  YAPPISGtI
Mutations Q/T
Epitope Location Q8T
HXB2 Location Q442T
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Note Variant 22, YAPPISGtI, binds Mamu-A*01 and is found at a frequency of 0.45% as opposed to 3.9% for HXB2-p41A epitopes in M group viruses.

References

Hulot2011 Sandrine L. Hulot, Evan M. Cale, Bette T. Korber, and Norman L. Letvin. Vaccine-Induced CD8+ T Lymphocytes of Rhesus Monkeys Recognize Variant Forms of an HIV Epitope but Do Not Mediate Optimal Functional Activity. J. Immunol., 186(10):5663-5674, 15 May 2011. PubMed ID: 21490161. Show all entries for this paper.


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