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Displaying record number 57821

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIILGLNK   escape documented in this paper; literature escape
KkWIvLGLNK   escape documented in this paper; literature escape
KgWIILGLNK   escape documented in this paper; inferred escape
KqWIILGLNK   escape documented in this paper; literature escape
KRWIImGLNK   susceptible form
Epitope Name KK10
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 5 variant(s).


Variant ID.  2642
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type E: escape documented in this paper
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Previously-documented escape mutant documented in B*27-positive patients. No response in B*27 individuals was seen in this study.


Variant ID.  2643
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIvLGLNK
Mutations R/K I/V
Epitope Location R2K I5V
HXB2 Location R264K I267V
Mutation Type E: escape documented in this paper
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Previously-documented escape mutant documented in B*27-positive patients. No response in B*27 individuals was seen in this study. Escape mutation is R2K.


Variant ID.  2644
Epitope Seq.  KRWIILGLNK
Variant Seq.  KgWIILGLNK
Mutations R/G
Epitope Location R2G
HXB2 Location R264G
Mutation Type E: escape documented in this paper
IE: inferred escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Previously-documented escape mutant documented in B*27-positive patients. No response in B*27 individuals was seen in this study.


Variant ID.  2645
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWIILGLNK
Mutations R/Q
Epitope Location R2Q
HXB2 Location R264Q
Mutation Type E: escape documented in this paper
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Previously-documented escape mutant documented in B*27-positive patients. No response in B*27 individuals was seen in this study.


Variant ID.  2648
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note A common susceptible variant. Substantial IFN-γ responses were measured from PBMCs stimulated with WT or L268M variant at pre-escape time points.

References

Ammaranond2011 Palanee Ammaranond, David J. van Bockel, Kathy Petoumenos, Marylin McMurchie, Robert Finlayson, Melanie G. Middleton, Miles P. Davenport, Vanessa Venturi, Kazuo Suzuki, Linda Gelgor, John M. Kaldor, David A. Cooper, and Anthony D. Kelleher. HIV Immune Escape at an Immunodominant Epitope in HLA-B*27-Positive Individuals Predicts Viral Load Outcome. J. Immunol., 186(1):479-488, 1 Jan 2011. PubMed ID: 21115730. Show all entries for this paper.


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