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Found 1 matching record:

Displaying record number 57768

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KxWIILGLNK   literature escape
KRWIIxGLNK   literature escape
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3054
Epitope Seq.  KRWIILGLNK
Variant Seq.  KxWIILGLNK
Mutations R/X
Epitope Location R2X
HXB2 Location R264X
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note Variant KxWIILGLNK, the KK10 R264X mutation has been linked to accelerated progression to AIDS. This mutation usually arises late and is typically followed by the KY9 G908E variant's emergence.


Variant ID.  3055
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIxGLNK
Mutations L/X
Epitope Location L6X
HXB2 Location L268X
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note Variant KRWIIxGLNK, the KK10 L268X mutation has a high escape rate with all subjects showing variation by 2 years post-infection.

References

Payne2010 Rebecca P. Payne, Henrik Kløverpris, Jonah B. Sacha, Zabrina Brumme, Chanson Brumme, Søren Buus, Stuart Sims, Stephen Hickling, Lynn Riddell, Fabian Chen, Graz Luzzi, Anne Edwards, Rodney Phillips, Julia G. Prado, and Philip J. R. Goulder. Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells. J. Virol., 84(20):10543-10557, Oct 2010. PubMed ID: 20686036. Show all entries for this paper.


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