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Found 1 matching record:

Displaying record number 57736

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
Variants
tPQVPLRPMTY   diminished response
Epitope Name RY11
Species (MHC/HLA human(B*35)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2634
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  tPQVPLRPMTY
Mutations R/T
Epitope Location R1T
HXB2 Location R71T
Mutation Type DR: diminished response
Note Variant to RY11, tPQVPLRPMTY, is seen to reduce antiviral CTL activity by a decline in proliferative capacity, Ueno et al., J. Immunol., 178:5513-23 (2007).

References

Motozono2010 Chihiro Motozono, Philip Mwimanzi, and Takamasa Ueno. Dynamic Interplay between Viral Adaptation and Immune Recognition during HIV-1 Infection. Protein Cell, 1(6):514-519, Jun 2010. PubMed ID: 21204005. Show all entries for this paper.


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