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Found 1 matching record:

Displaying record number 57720

HXB2 Location  Pol(273-282)   Pol Epitope Map
View variants at this location
Epitope VPLDEDFRKY   Epitope Alignment
Variants
iPLDEDFRKY   HLA association; non-susceptible form; susceptible form
VPLDkDFRKY   observed variant
VPLDkxFRKY   observed variant
VPLDEnFRKY   observed variant
VPLDxxFRKY   observed variant
Epitope Name VY10
Species (MHC/HLA human(B*35)

Variant Details

Showing all: 5 variant(s).


Variant ID.  2612
Epitope Seq.  VPLDEDFRKY
Variant Seq.  iPLDEDFRKY
Mutations V/I
Epitope Location V1I
HXB2 Location V273I
Mutation Type A: HLA association
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note Variant iPLDEDFRKY was recognized by CTL from HLA-B*35-Px+ subjects but not by CTL from HLA-B*35-Py+ subjects.


Variant ID.  2613
Epitope Seq.  VPLDEDFRKY
Variant Seq.  VPLDkDFRKY
Mutations E/K
Epitope Location E5K
HXB2 Location E277K
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Variant VPLDkDFRKY was seen in Subjects 1 & 5, HLA-B*35-Px expressing rapid progressors at 653 and 30 weeks post-infection.


Variant ID.  2614
Epitope Seq.  VPLDEDFRKY
Variant Seq.  VPLDkxFRKY
Mutations E/K D/X
Epitope Location E5K D6X
HXB2 Location E277K D278X
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Variant VPLDkxFRKY was seen in Subject 2, an HLA-B*35-Px expressing rapid progressor at 92 weeks post-infection.


Variant ID.  2615
Epitope Seq.  VPLDEDFRKY
Variant Seq.  VPLDEnFRKY
Mutations D/N
Epitope Location D6N
HXB2 Location D278N
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Variant VPLDEnFRKY was seen in Subject 4, an HLA-B*35-Px expressing rapid progressor at 10 and 134 weeks post-infection.


Variant ID.  2616
Epitope Seq.  VPLDEDFRKY
Variant Seq.  VPLDxxFRKY
Mutations E/X D/X
Epitope Location E5X D6X
HXB2 Location E277X D278X
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Variant VPLDxxFRKY was seen in Subject 6, an HLA-B*35-Px expressing rapid progressor at 61 weeks post-infection.

References

Willberg2010 Christian B. Willberg, Keith E. Garrison, R. Brad Jones, Duncan J. Meiklejohn, Gerald Spotts, Teri J. Liegler, Mario A. Ostrowski, Annika C. Karlsson, Frederick M. Hecht, and Douglas F. Nixon. Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes. PLoS One, 5(4):e10249, 2010. PubMed ID: 20422053. Show all entries for this paper.


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