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Displaying record number 57672

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
Variants
tPQVPLRPMTY   escape documented in this paper
tPQVPLRPMTf   escape documented in this paper
Epitope Name RY11
Species (MHC/HLA human(B*3501)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2577
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  tPQVPLRPMTY
Mutations R/T
Epitope Location R1T
HXB2 Location R71T
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note RPQVPLRPMTY-specific CTLs did not respond to cells expressing tPQVPLRPMTY and tPQVPLRPMTf variants.


Variant ID.  2578
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  tPQVPLRPMTf
Mutations R/T Y/F
Epitope Location R1T Y11F
HXB2 Location R71T Y81F
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note RPQVPLRPMTY-specific CTLs did not respond to cells expressing tPQVPLRPMTY and tPQVPLRPMTf variants.

References

Mwimanzi2010 Philip Mwimanzi, Zafrul Hasan, Michiyo Tokunaga, Hiroyuki Gatanaga, Shinichi Oka, and Takamasa Ueno. Naturally Arising HIV-1 Nef Variants Conferring Escape from Cytotoxic T Lymphocytes Influence Viral Entry Co-Receptor Expression and Susceptibility to Superinfection. Biochem. Biophys. Res. Commun., 403(3-4):422-427, 17 Dec 2010. PubMed ID: 21093412. Show all entries for this paper.


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