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Displaying record number 57636

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   escape documented in this paper
TAFTIPSr   escape documented in this paper
TAFTIPSl   escape documented in this paper
Epitope Name Pol 283-8
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2562
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Flow cytometric T-cell cytokine assay, Longitudinal study
Note Pol 283-8-specific CTL clones failed to kill target cells infected with Pol283-8T mutant. Longitudinal study of one patient showed appearance of the 8T mutant at the same time as increase in viral load.


Variant ID.  2563
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Flow cytometric T-cell cytokine assay
Note Pol 283-8-specific CTL clones failed to kill target cells infected with Pol283-8R mutant.


Variant ID.  2564
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSl
Mutations I/L
Epitope Location I8L
HXB2 Location I290L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Flow cytometric T-cell cytokine assay
Note Pol 283-8-specific CTL clones failed to kill target cells infected with Pol283-8L mutant.

References

Kawashima2010 Yuka Kawashima, Nozomi Kuse, Hiroyuki Gatanaga, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi. Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B*5101. J. Virol., 84(14):7151-7160, Jul 2010. PubMed ID: 20410273. Show all entries for this paper.


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