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Displaying record number 57605

HXB2 Location Pol(155-163) Pol Epitope Map
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Epitope

FPISPIETV

Epitope Alignment

Variants

FPISPIdTV escape documented in this paper

Epitope Name FV9

Species (MHC/HLA) human(B*54:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2558`
Epitope Seq.	`FPISPIETV`
Variant Seq.	`FPISPIdTV`
Mutations	E/D
Epitope Location	E7D
HXB2 Location	E161D
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Longitudinal study, Relative replication capacity assay, Sequence
Note	FV9-specific CTLs showed reduced killing activity against target cells pulsed with the FV9-7D mutant (FPISPIdTV) peptide and failed to kill those infected with the FV9-7D mutant virus; in 2 HLA-B*5401 individuals the mutant appeared during the clinical course, suggesting escape.

References

Hashimoto2010 Masao Hashimoto, Mitsutaka Kitano, Kazutaka Honda, Hirokazu Koizumi, Sachi Dohki, Shinichi Oka, and Masafumi Takiguchi. Selection of Escape Mutation by Pol154-162-Specific Cytotoxic T Cells among Chronically HIV-1-Infected HLA-B*5401-Positive Individuals. Hum. Immunol., 71(2):123-127, Feb 2010. PubMed ID: 19891998. Show all entries for this paper.