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Found 1 matching record:

Displaying record number 57605

HXB2 Location  Pol(155-163)   Pol Epitope Map
View variants at this location
Epitope FPISPIETV   Epitope Alignment
Variants
FPISPIdTV   escape documented in this paper
Epitope Name FV9
Species (MHC/HLA human(B*54:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2558
Epitope Seq.  FPISPIETV
Variant Seq.  FPISPIdTV
Mutations E/D
Epitope Location E7D
HXB2 Location E161D
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Longitudinal study, Relative replication capacity assay, Sequence
Note FV9-specific CTLs showed reduced killing activity against target cells pulsed with the FV9-7D mutant (FPISPIdTV) peptide and failed to kill those infected with the FV9-7D mutant virus; in 2 HLA-B*5401 individuals the mutant appeared during the clinical course, suggesting escape.

References

Hashimoto2010 Masao Hashimoto, Mitsutaka Kitano, Kazutaka Honda, Hirokazu Koizumi, Sachi Dohki, Shinichi Oka, and Masafumi Takiguchi. Selection of Escape Mutation by Pol154-162-Specific Cytotoxic T Cells among Chronically HIV-1-Infected HLA-B*5401-Positive Individuals. Hum. Immunol., 71(2):123-127, Feb 2010. PubMed ID: 19891998. Show all entries for this paper.


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