HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Pol(283-290) | Pol Epitope Map
View variants at this location |
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| Epitope |
TAFTIPSI
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Epitope Alignment | |||||||||||||
| Variants |
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| Species (MHC/HLA) | human(B*51) | ||||||||||||||
Showing all: 4 variant(s).
| Variant ID. | 2522 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSl |
| Mutations | I/L |
| Epitope Location | I8L |
| HXB2 Location | I290L |
| Mutation Type | E: escape documented in this paper |
| Method | Sequence |
| Note | This escape, TAFTIPSl, did not confer significant resistance to NNRTI. During passages of virus with I135L, however, rare variant E138K also emerged. I135l, E138K together did confer significant resistance to NVP. Other variants that occurred with this escape were K103R and V179D, both of which do confer significant NNRTI-resistance. Variants V108I, V106A, L100I, G190A also arose and are listed as resistance mutations in the IAS-USA table. |
| Variant ID. | 2523 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSv |
| Mutations | I/V |
| Epitope Location | I8V |
| HXB2 Location | I290V |
| Mutation Type | E: escape documented in this paper |
| Method | Sequence |
| Note | This escape, TAFTIPSv, did not confer significant resistance to NNRTI. During passages of virus with I135L, however, rare variant E138K also emerged. I135V, E138K together did confer significant resistance to ETR and EFV. Other variants that occurred with this escape were L100I followed by Y188H, and L100I followed by V108I. |
| Variant ID. | 2524 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSt |
| Mutations | I/T |
| Epitope Location | I8T |
| HXB2 Location | I290T |
| Mutation Type | E: escape documented in this paper |
| Method | Sequence |
| Note | This most frequent escape, TAFTIPSt, did not confer significant resistance to NNRTI. During passages of virus with I135T, however, rare variant E138K also emerged. I135T, E138K together did confer significant resistance to EFV, NVP and ETR. Other variants that occurred with this escape were V108I and K101E. Variant V106I was followed by V179D which together do confer significant NNRTI-resistance. |
| Variant ID. | 2525 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSr |
| Mutations | I/R |
| Epitope Location | I8R |
| HXB2 Location | I290R |
| Mutation Type | E: escape documented in this paper |
| Method | Sequence |
| Note | This escape, TAFTIPSr, did not confer significant resistance to NNRTI. During passages of virus with I135L, however, rare variant E138K also emerged. I135R, E138K together did confer significant resistance to ETR. Other variants that occurred with this escape were K103R and V179D, both of which do confer significant NNRTI-resistance. Variants V108I, V106A, L100I, G190A also arose and are listed as resistance mutations in the IAS-USA table. |
Gatanaga2010 Hiroyuki Gatanaga, Hirotaka Ode, Atsuko Hachiya, Tsunefusa Hayashida, Hironori Sato, Masafumi Takiguchi, and Shinichi Oka. Impact of Human Leukocyte Antigen-B*51-Restricted Cytotoxic T-Lymphocyte Pressure on Mutation Patterns of Nonnucleoside Reverse Transcriptase Inhibitor Resistance. AIDS, 24(5):F15-F22, 13 Mar 2010. PubMed ID: 20160632. Show all entries for this paper.