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Displaying record number 57505

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSl   escape documented in this paper
TAFTIPSv   escape documented in this paper
TAFTIPSt   escape documented in this paper
TAFTIPSr   escape documented in this paper
Species (MHC/HLA human(B*51)

Variant Details

Showing all: 4 variant(s).


Variant ID.  2522
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSl
Mutations I/L
Epitope Location I8L
HXB2 Location I290L
Mutation Type E: escape documented in this paper
Method Sequence
Note This escape, TAFTIPSl, did not confer significant resistance to NNRTI. During passages of virus with I135L, however, rare variant E138K also emerged. I135l, E138K together did confer significant resistance to NVP. Other variants that occurred with this escape were K103R and V179D, both of which do confer significant NNRTI-resistance. Variants V108I, V106A, L100I, G190A also arose and are listed as resistance mutations in the IAS-USA table.


Variant ID.  2523
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type E: escape documented in this paper
Method Sequence
Note This escape, TAFTIPSv, did not confer significant resistance to NNRTI. During passages of virus with I135L, however, rare variant E138K also emerged. I135V, E138K together did confer significant resistance to ETR and EFV. Other variants that occurred with this escape were L100I followed by Y188H, and L100I followed by V108I.


Variant ID.  2524
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type E: escape documented in this paper
Method Sequence
Note This most frequent escape, TAFTIPSt, did not confer significant resistance to NNRTI. During passages of virus with I135T, however, rare variant E138K also emerged. I135T, E138K together did confer significant resistance to EFV, NVP and ETR. Other variants that occurred with this escape were V108I and K101E. Variant V106I was followed by V179D which together do confer significant NNRTI-resistance.


Variant ID.  2525
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type E: escape documented in this paper
Method Sequence
Note This escape, TAFTIPSr, did not confer significant resistance to NNRTI. During passages of virus with I135L, however, rare variant E138K also emerged. I135R, E138K together did confer significant resistance to ETR. Other variants that occurred with this escape were K103R and V179D, both of which do confer significant NNRTI-resistance. Variants V108I, V106A, L100I, G190A also arose and are listed as resistance mutations in the IAS-USA table.

References

Gatanaga2010 Hiroyuki Gatanaga, Hirotaka Ode, Atsuko Hachiya, Tsunefusa Hayashida, Hironori Sato, Masafumi Takiguchi, and Shinichi Oka. Impact of Human Leukocyte Antigen-B*51-Restricted Cytotoxic T-Lymphocyte Pressure on Mutation Patterns of Nonnucleoside Reverse Transcriptase Inhibitor Resistance. AIDS, 24(5):F15-F22, 13 Mar 2010. PubMed ID: 20160632. Show all entries for this paper.


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