HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 57502

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGIRYPL   Epitope Alignment
TPGPGvRYPL   HLA association; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).

Variant ID.  2517
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRYPL
Mutations I/V
Epitope Location I6V
HXB2 Location I133V
Mutation Type A: HLA association
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note This 'adapted epitope' or variant from the polyallelic peptide set was part of the 13 central Nef adapted epitopes, 7 of which elicited responses in >20% of responders. Epitope TPGPGvRYPL was able to elicit a response in 24% of responding subjects. It is restricted by HLA B*07, B*35 and B*42.


Almeida2010 Coral-Ann M. Almeida, Steven G. Roberts, Rebecca Laird, Elizabeth McKinnon, Imran Ahmad, Niamh M. Keane, Abha Chopra, Carl Kadie, David Heckerman, Simon Mallal, and Mina John. Exploiting Knowledge of Immune Selection in HIV-1 to Detect HIV-Specific CD8 T-Cell Responses. Vaccine, 28(37):6052-6057, 23 Aug 2010. PubMed ID: 20619380. Show all entries for this paper.

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