HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Nef(128-137) | Nef Epitope Map
View variants at this location |
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| Epitope |
TPGPGIRYPL
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human | |||||
Showing all: 1 variant(s).
| Variant ID. | 2517 |
|---|---|
| Epitope Seq. | TPGPGIRYPL |
| Variant Seq. | TPGPGvRYPL |
| Mutations | I/V |
| Epitope Location | I6V |
| HXB2 Location | I133V |
| Mutation Type | A: HLA association SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | This 'adapted epitope' or variant from the polyallelic peptide set was part of the 13 central Nef adapted epitopes, 7 of which elicited responses in >20% of responders. Epitope TPGPGvRYPL was able to elicit a response in 24% of responding subjects. It is restricted by HLA B*07, B*35 and B*42. |
Almeida2010 Coral-Ann M. Almeida, Steven G. Roberts, Rebecca Laird, Elizabeth McKinnon, Imran Ahmad, Niamh M. Keane, Abha Chopra, Carl Kadie, David Heckerman, Simon Mallal, and Mina John. Exploiting Knowledge of Immune Selection in HIV-1 to Detect HIV-Specific CD8 T-Cell Responses. Vaccine, 28(37):6052-6057, 23 Aug 2010. PubMed ID: 20619380. Show all entries for this paper.