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Found 1 matching record:

Displaying record number 57501

HXB2 Location  Nef(92-100)   Nef Epitope Map
View variants at this location
Epitope KEKGGLEGL   Epitope Alignment
Variants
KEKGGLEGi   HLA association; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  2516
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEGi
Mutations L/I
Epitope Location L9I
HXB2 Location L100I
Mutation Type A: HLA association
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note This 'adapted epitope' or variant from the polyallelic peptide set was part of the 13 central Nef adapted epitopes, 7 of which elicited responses in >20% of responders. Epitope KEKGGLEGi was able to elicit a response in 24% of responding subjects. It is restricted by HLA B*40.

References

Almeida2010 Coral-Ann M. Almeida, Steven G. Roberts, Rebecca Laird, Elizabeth McKinnon, Imran Ahmad, Niamh M. Keane, Abha Chopra, Carl Kadie, David Heckerman, Simon Mallal, and Mina John. Exploiting Knowledge of Immune Selection in HIV-1 to Detect HIV-Specific CD8 T-Cell Responses. Vaccine, 28(37):6052-6057, 23 Aug 2010. PubMed ID: 20619380. Show all entries for this paper.


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