HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 57473

HXB2 Location  gp160(352-361)   gp160 Epitope Map
View variants at this location
Epitope QFRNKTIVF   Epitope Alignment
QFkNKTIVF   escape documented in this paper
Species (MHC/HLA human(C*04:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.  2455
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFkNKTIVF
Mutations R/K
Epitope Location R3K
HXB2 Location R354K
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note One patient who had positive responses to previously-reported Cw*0401 epitope QFRNKTIVF and to the corresponding 18-mer REQFRNKTIVFNHSSGGD also had negative responses to two common transmitted variant 18-mers, REQFkNKTIVFNHSSGGD and LSHVVDKLREQFkNKTIV.


Wood2009 Natasha Wood, Tanmoy Bhattacharya, Brandon F. Keele, Elena Giorgi, Michael Liu, Brian Gaschen, Marcus Daniels, Guido Ferrari, Barton F. Haynes, Andrew McMichael, George M. Shaw, Beatrice H. Hahn, Bette Korber, and Cathal Seoighe. HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC. PLoS Pathog., 5(5):e1000414, May 2009. PubMed ID: 19424423. Show all entries for this paper.

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