HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 57333

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
Variants
tPQVPLRPMTY   escape documented in this paper; TCR related mutation
Epitope Name Nef75
Species (MHC/HLA human(B35)

Variant Details

Showing all: 1 variant(s).


Variant ID.  8
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  tPQVPLRPMTY
Mutations R/T
Epitope Location R1T
HXB2 Location R71T
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Epitope Subtype B
Variant Subtype B
Method Cytotoxicity assay, Flow cytometric T-cell cytokine assay, Sequence, TCR binding
Note Escape variant tPQVPLRPMTY was documented on the basis of sequence frequency in B35-positive patients, abolished TCR binding, flow cytometric assay, and cytotoxicity assay.

References

Ueno2007 Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-Specific CTLs. J. Immunol., 178(9):5513-5523, 1 May 2007. PubMed ID: 17442933. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health