HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 57333

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
tPQVPLRPMTY   escape documented in this paper; TCR related mutation
Epitope Name Nef75
Species (MHC/HLA human(B35)

Variant Details

Showing all: 1 variant(s).

Variant ID.  8
Variant Seq.  tPQVPLRPMTY
Mutations R/T
Epitope Location R1T
HXB2 Location R71T
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Epitope Subtype B
Variant Subtype B
Method Cytotoxicity assay, Flow cytometric T-cell cytokine assay, Sequence, TCR binding
Note Escape variant tPQVPLRPMTY was documented on the basis of sequence frequency in B35-positive patients, abolished TCR binding, flow cytometric assay, and cytotoxicity assay.


Ueno2007 Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-Specific CTLs. J. Immunol., 178(9):5513-5523, 1 May 2007. PubMed ID: 17442933. Show all entries for this paper.

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