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Found 1 matching record:

Displaying record number 56658

HXB2 Location  Vif(119-127)   Vif Epitope Map
View variants at this location
Epitope AIRKAILGR   Epitope Alignment
Variants
AIRKAlLGR   inferred escape
AIRKAIvGR   inferred escape
AIRtAILGR   inferred escape
AIReAILGR   inferred escape
{dS}AIReAILGR   inferred escape; processing
Species (MHC/HLA human

Variant Details

Showing all: 5 variant(s).


Variant ID.  2083
Epitope Seq.  AIRKAILGR
Variant Seq.  AIRKAlLGR
Mutations I/L
Epitope Location I6L
HXB2 Location I124L
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note Patient CH40 carried this mutant, and at the same time lost response to the original epitope.


Variant ID.  2084
Epitope Seq.  AIRKAILGR
Variant Seq.  AIRKAIvGR
Mutations L/V
Epitope Location L7V
HXB2 Location L125V
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note Patient CH40 carried this mutant, and at the same time lost response to the original epitope.


Variant ID.  2085
Epitope Seq.  AIRKAILGR
Variant Seq.  AIRtAILGR
Mutations K/T
Epitope Location K4T
HXB2 Location K122T
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note Patient CH40 carried this mutant, and at the same time lost response to the original epitope.


Variant ID.  2086
Epitope Seq.  AIRKAILGR
Variant Seq.  AIReAILGR
Mutations K/E
Epitope Location K4E
HXB2 Location K122E
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note Patient CH40 carried this mutant, and at the same time lost response to the original epitope.


Variant ID.  2329
Epitope Seq.  {ES}AIRKAILGR
Variant Seq.  {dS}AIReAILGR
Mutations E/D K/E
Epitope Location E-2D K4E
HXB2 Location E117D K122E
Mutation Type IE: inferred escape
P: processing
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note Patient CH40 carried this mutant, and at the same time lost response to the original epitope.

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.


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