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Displaying record number 56642

HXB2 Location  gp160(352-361)   gp160 Epitope Map
View variants at this location
Epitope QFRNKTIVF   Epitope Alignment
Variants
QFkNKTIVF   escape documented in this paper
QFsNKTIVF   observed variant
QFnNKTIVF   observed variant
QFRNKaIVF   observed variant
QFkNKaIVF   observed variant
QFkdKTIVF   observed variant
Species (MHC/HLA human

Variant Details

Showing all: 6 variant(s).


Variant ID.  2033
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFkNKTIVF
Mutations R/K
Epitope Location R3K
HXB2 Location R354K
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note This newly described epitope showed escape early on in Patient CH77. Known T cell response from the full proteome scan with evidence for variation and escape was seen.


Variant ID.  2034
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFsNKTIVF
Mutations R/S
Epitope Location R3S
HXB2 Location R354S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note This newly described epitope showed escape early on in Patient CH77. Known T cell response from the full proteome scan with evidence for variation and escape was seen.


Variant ID.  2035
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFnNKTIVF
Mutations R/N
Epitope Location R3N
HXB2 Location R354N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note This newly described epitope showed escape early on in Patient CH77. Known T cell response from the full proteome scan with evidence for variation and escape was seen.


Variant ID.  2036
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFRNKaIVF
Mutations T/A
Epitope Location T6A
HXB2 Location T357A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note This newly described epitope showed escape early on in Patient CH77. Known T cell response from the full proteome scan with evidence for variation and escape was seen.


Variant ID.  2037
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFkNKaIVF
Mutations R/K T/A
Epitope Location R3K T6A
HXB2 Location R354K T357A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note This newly described epitope showed escape early on in Patient CH77. There was no response to the R3K mutant; R3K, T6A was not tested.


Variant ID.  2038
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFkdKTIVF
Mutations R/K N/D
Epitope Location R3K N4D
HXB2 Location R354K N355D
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note This newly described epitope showed escape early on in Patient CH77. There was no response to the R3K mutant; R3K, N4D was not tested.

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.


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