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Displaying record number 565

HXB2 Location Pol(593-603) Pol Epitope Map
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Epitope

ETFYVDGAANR

Epitope Alignment

Variants

ETyYVnGAANR diminished response

Species (MHC/HLA) human(A26)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1850`
Epitope Seq.	`ETFYVDGAANR`
Variant Seq.	`ETyYVnGAANR`
Mutations	F/Y D/N
Epitope Location	F3Y D6N
HXB2 Location	F595Y D598N
Mutation Type	DR: diminished response
Method	Chromium-release assay
Note	This variant showed reduced CTL recognition by a non-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.