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Found 1 matching record:

Displaying record number 565

HXB2 Location  Pol(593-603)   Pol Epitope Map
View variants at this location
Epitope ETFYVDGAANR   Epitope Alignment
Variants
ETyYVnGAANR   diminished response
Species (MHC/HLA human(A26)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1850
Epitope Seq.  ETFYVDGAANR
Variant Seq.  ETyYVnGAANR
Mutations F/Y D/N
Epitope Location F3Y D6N
HXB2 Location F595Y D598N
Mutation Type DR: diminished response
Method Chromium-release assay
Note This variant showed reduced CTL recognition by a non-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


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