HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 56302

HXB2 Location  Nef(101-109)   Nef Epitope Map
View variants at this location
Epitope IHSQRRQDI   Epitope Alignment
IySQkRQDI   susceptible form
Species (MHC/HLA human(A24)

Variant Details

Showing all: 1 variant(s).

Variant ID.  161
Epitope Seq.  IHSQRRQDI
Variant Seq.  IySQkRQDI
Mutations H/Y R/K
Epitope Location H2Y R5K
HXB2 Location H102Y R105K
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note IHSQRRQDI, elicited a response in 1 patient. Patient autologous sequence was IySQkRQDI, which was exclusively targeted over the consensus form IHSQRRQDI.


Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.

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