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Found 1 matching record:

Displaying record number 56266

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KgWIILGLNK   literature escape
Species (MHC/HLA human(B27)

Variant Details

Showing all: 1 variant(s).


Variant ID.  194
Epitope Seq.  KRWIILGLNK
Variant Seq.  KgWIILGLNK
Mutations R/G
Epitope Location R2G
HXB2 Location R264G
Mutation Type LE: literature escape
Note Mutation of the peptide sequence EIYKRWIILGLNK to dIYKgWIILGLNK was seen only in 1 subject who exhibited delayed progression to viremia and who initiated ART, but succumbed to non-AIDS death at age 83. This is escape mutant was characterized previously.

References

Dyer2008 Wayne B. Dyer, John J. Zaunders, Fang Fang Yuan, Bin Wang, Jennifer C. Learmont, Andrew F. Geczy, Nitin K. Saksena, Dale A. McPhee, Paul R. Gorry, and John S. Sullivan. Mechanisms of HIV Non-Progression; Robust and Sustained CD4+ T-Cell Proliferative Responses to p24 Antigen Correlate with Control of Viraemia and Lack of Disease Progression after Long-Term Transfusion-Acquired HIV-1 Infection. Retrovirology, 5:112, 2008. PubMed ID: 19077215. Show all entries for this paper.


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