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Found 1 matching record:

Displaying record number 56053

HXB2 Location  Pol(530-538)   Pol Epitope Map
View variants at this location
Epitope IATESIVIW   Epitope Alignment
Variants
IAmESIVIW   observed variant
Epitope Name IW9(RT)
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1924
Epitope Seq.  IATESIVIW
Variant Seq.  IAmESIVIW
Mutations T/M
Epitope Location T3M
HXB2 Location T532M
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This Asian B Clade optimal epitope differs from the consensus B at one position. It is predicted to be HLA-B58 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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